Saugeen Shores Police investigated a single vehicle rollover Monday morning on Bruce Road 17.
The incident occurred east of Port Elgin just before 6 am.
The lone occupant of the vehicle was ejected from the driver's seat and suffered significant injuries.
The driver was air lifted to hospital in London.
Bruce Road 17 was closed for a period during the investigation but has now been re-opened.
Anyone with information on the incident is asked to contact Saugeen Shores Police.